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New therapy for advanced prostate cancer available in Trinidad & Tobago


Prostate cancer is the most common tumor affecting men in Trinidad

A new therapeutic option has been recently approved in Trinidad & Tobago and is available
for patients with metastatic castration-resistant prostate cancer, progressing to chemotherapy

PORT OF SPAIN, Trinidad & Tobago, April 11, 2014 /PRNewswire/ — The Chemistry, Food & Drugs Division of the

Trinidad & Tobago Ministry of Health approved the introduction of Abiraterone Acetate to the country,
the first – orally administered androgen synthesis inhibitor (testosterone) medication for the treatment of
patients with metastatic castration-resistant prostate cancer.

New Therapy For Advanced Prostate Cancer Available In Trinidad & Tobago

Clinical trials have demonstrated that this new therapeutic resource for the standard therapy of patients with
hormone-resistant tumors reduces the risk of death by approximately 35%.  Abiraterone Acetate is available
in Trinidad & Tobago under the trademark Zytiga™.

According to the National Cancer Registry of Trinidad & Tobago, prostate cancer leads cancer statistics in
the population with 22% of all cases. Amongst males, prostate cancer accounted for 42% of all new cases
of cancer. Worldwide, prostate cancer is the second type of cancer most frequently diagnosed in men, and
the fifth type overall. Near 1.1 million new cases of prostate cancer were diagnosed worldwide in 2012, and
more than 300,000 men died because of the disease.

This type of cancer is the result of the malignant transformation of certain cells of the prostate, a gland located
underneath the urinary bladder in men, one of the functions of which is to produce a part of the seminal fluid.

Although a slowly developing disease, some prostate tumors may be very aggressive and extend quickly to
invade other organs (metastasis).

Abiraterone Acetate is a new therapy administered orally as a single daily dose, which prevents androgen
from being produced at their three sources: Testes, adrenal glands, and the tumor itself, through the strong
block of the CYP 17 enzyme.

Androgens are hormones that promote both male development and sexual features, and prostate cancer cells
have been shown to need them to grow.

“Abiraterone Acetate is an androgen synthesis inhibitor (testosterone) treatment that reduces the risk of death
by approximately 35% of patients already treated with hormone therapy and chemotherapy. Approximately 20%
of all patients with prostate cancer progress to a severe stage of the disease and could now benefit from this new
therapeutic alternative”, stated Dr. Carmen Martinez, Medical Director of Janssen for Venezuela, Central America
and the Caribbean.

One of the most salient aspects of Abiraterone Acetate that distinguishes it from other oncologic treatments is
that it possesses a novel mechanism of action, with a benefit as to the overall survival rate, and a tolerable
toxicity profile.

Additionally, Abiraterone Acetate also provides relief for bone pain that often afflicts patients at advanced stages
of the disease.

“Before the appearance of Abiraterone Acetate, after progressing to chemotherapy most patients received either a
second unsuccessful line of therapy or merely supportive, palliative treatment” added Dr. Martínez.

The treatment of this condition depends on its stage at diagnosis. Prostatectomy (surgical removal of the prostate),
hormone block, or radiotherapy, are some therapeutic possibilities available for the treatment of this disease.
The primary objective of treatment in patients with advanced prostate cancer is to block the action of androgens
such as testosterone, since this may result in the regression of the tumor whose development is stimulated
by this hormone.
However, with passing time many patients who had initially responded to treatments aimed at blocking the production
of testosterone, start to produce the hormone again, which reactivates the disease.

Chemotherapy is used in those cases in which the disease has become castration-resistant, that is, that the
prostate cancer has kept progressing despite treatment, thus exhausting the possibilities to carry out or to
continue the hormone block.
Some treatments available for these patients are intravenous chemotherapies, with this group including only
docetaxel and mitoxantrone until 2010.

About Janssen

Janssen is a company devoted to research to provide innovative products that help protect and improve the lives
of people, to face and solve the most significant and still unmet medical needs in the areas of oncology,
immunology, neurosciences, and infectious, cardiovascular, and metabolic diseases.
Through the different companies of the Johnson & Johnson group, our staff is united in the passionate search
for solutions through science, for the benefit of our patients.

With presence in more than 50 countries, we share the commitment of the founders of our company to innovate
in ideas, products, and services for our patients all around the world.

Press Contact:


Joan Townsend

(507) 64306252 / (507) 3067006


Cesar Ortega

Ejecutivo de Cuenta. Stratego

Tel.  (507) 270-3433

Foto: http://photos.prnewswire.com/prnh/20140411/MX04085